Monday, August 26, 2019
THE EFFECT OF DRUGS ON PEOPLE WITH BIPOLAR DISORDER Term Paper
THE EFFECT OF DRUGS ON PEOPLE WITH BIPOLAR DISORDER - Term Paper Example Depressive disorders impress the direction a persons head purposes. Bipolar disorder becomes by a lot of names: bipolar disorder, diseased person disorder, diseased person illness, bipolar temper disorder, and bipolar emotional disorder are medical phrases for the identical circumstance (Smith, 2009). Bipolar disorder is broadly classified addicted to four unlike categories: Bipolar I, Bipolar II, Cyclothymic Disorder, or Bipolar Disorder not Differently Determined. The health individuals distinguish the discipline into these four categories for the reason that the symptoms of bipolar disorder demonstrate up in a different ways as well as in dissimilar people. When doctors experience what kind somebody has, they be capable of tailor management to that persons particular demands (Guyol, 2006). The antidepressant medications which are almost frequently used to handle depressive disorders: are by and large divided into three groups these are tricyclics, monoamine oxidase inhibitors (MAOIs), and lithium. Lithium has and then for been the a good number effected choice for by bipolar disorder in addition to a number of outlines of returning, most important depression. On the other hand, further lately doctors have also been by means of anticonvulsants for bipolar disorder (Guyol, 2006). Your general practitioner be obliged to think your personal health times gone by and reply to medications in finding out what is most beneficial for you. Every now and then different medicines are tried, and occasionally the quantity must be improved to be successful. People are in practice of blocking medicine early which is not in thier favor indeed. It is significant to continue taking medicine till your doctor says to discontinue, yet if you must be aware of enhanced in advance. A number of medications are required to be stopped slowly but surely to provide your body time to regulate. For individuals with bipolar
Sunday, August 25, 2019
Analysis of Personal and Organizational Ethics and Values between Research Paper
Analysis of Personal and Organizational Ethics and Values between For-Profit and Not-for-Profit Organizations - Research Paper Example Various companies claim to have the best corporate environment in their respective cultures but there are several discrepancies and deviations in them. Abolishment of organizational ethics can be observed in companies and yet they claim to be the best in market. The purpose of this paper is to examine such circumstances in a profit organization- Apple Inc. and a nonprofit organization- International Red Crescent. What sort of organizational ethics play into action in these firms and how are they following the code of ethics is the essence of the paper. What kind of culture is prevailing in the decision making process- authoritative or democratic etc. Examining the current status of employees, management practices and their relationship with the ethical management theories will be illustrated. What processes the companies have applied to remain competitive in the industry and are the mission & vision matching with their respective actions etc or not. In depth analysis of both these co mpanies will be done to acquire concrete knowledge. Part 1: International Red Cross: Company Profile The International Red Cross movement is a world renowned nonprofit humanitarian movement for the welfare of human race. It has the legacy to help out human beings irrespective of any race, color or religion. The motto of this movement is to protect human lives, cure them from diseases and prevent their sufferings. This movement has been working globally having stations in almost every country of the world. The Red Cross movement has its subsidiaries working in countries by the name of National Red Cross; however the mother organization remains as International Red Cross. Red Cross joined hands with the Red Crescent movement so that humanitarian services would be expanded and an overall impact all over the globe could be made. The efforts of the merger of both these organizations gave a powerful message that humanity first. The establishment of International Red Cross and Red Crescent movement was essential as they got immense aid and their humanitarian services also spread out. This movement is highly acknowledged by the governments of the world and in the time of war, floods, earthquakes or any unpleasant circumstances; International Red Cross & Red Crescent are the front row saviors of human lives. They have well qualified doctors, physicians, rescue team and technology. Due to their enormous fame and great services, government and people whole heartedly aid this organization. The efforts laid by Red Cross are verily outstanding and commendable. Ethical Dilemma at Red Cross Every organization faces tough and hard circumstances through which it has to pass victorious. Red Cross has faced several ethical dilemmas and it occurred due to numerous reasons. The biggest issue which Red Cross has been facing is the logistics problem. Logistics and Supply chain management is a big setback in the serving efforts of the organization. The proper management and allocation process still needs to be examined. There is no doubt about the services provided by Red Cross but most of them it is observed that there process is slowed down due to delay in supplies. The supply chain management department of Red Crescent has not been so active in the years and their service has not been up to the mark (Van Wassenhove, 2005). Delays in facilitating the affected masses have been due to shortage of supplies in which the negligence of supply chain department and
Saturday, August 24, 2019
Read the column by Eugene Robinson about the Trayvon Martin shooting Essay
Read the column by Eugene Robinson about the Trayvon Martin shooting. Summarize the main point he is trying to make, and discuss how he uses history to make his point - Essay Example He usesà historyà toà determineà that racism is not a new phenomenon but anà actà that has been inà occurrenceà since prehistorical times. Theà blackà men have always had aà markà on them against all evils and have had to tread carefully wherever and whenever they went. Historically racism directed to all nonà whiteà populations, but currently even other non white races discriminate against the black. For instance, the discrimination of Zimmerman, who is Hispanic, against a blackà Trayvon. Through history, heà furtherà criticizes and mocks the legal and social practices within the societies today. Racism in the past, such as the killing of Till at 14 in Mississippi for flirting with a white woman, was anà evilà actà even though it had mutualà recognitionà and practice among all races. In present society, there are laws against racism, and that seems to be accepted within society which make it even more troubling that such acts stillà occurà today such as the killing ofà Trayvonà martin for walking the ââ¬Å"wrong place andà timeâ⬠. Even with a black family in the white house and all seaming well, such acts stillà occurà in society and the lawà stillà finds loopholes to defend their
Friday, August 23, 2019
Personal Bankruptcy Essay Example | Topics and Well Written Essays - 500 words
Personal Bankruptcy - Essay Example Section 316 of the Act requires the creditors to mention any additional income such as those from family is expected in the following year. A petitioner whose bankruptcy case had been previously adjudicated will have to wait for 8 years before filing another claim. The new act also allows conversions of liquidation into wage earner plans and liquidation cases in which the debtorââ¬â¢s income falls under a certain level will only be considered. Petitioner can use the exemptions allowed by the state only if they have resided in the state for at least 730 days. With regard to their houses, the creditors are allowed to exempt the first $125,000 of the value only if the home was purchased within a period of 1215 days. In case a tenant, who is using the home for illegal purposes, files a bankruptcy against the owner, section 311 of the Act would still allow the owner to evict the tenant. Credit card charges made for purchase of luxury goods for a minimum of $500 should be paid within 90 days of the credit and the limits for cash advances are $750 and student loans are dischargeable according to section 310 of the Act. However, the Act still protects the $1,000,000 of a debtorââ¬â¢s retirement benefits. The education savings account is also exempted if the funds have been placed into the account one or two years prior to filing for bankruptcy. In case of auto loans, if a debtor files for bankruptcy, he would be expected to pay only a secured portion of the auto loan in order to retain the vehicle with him. In case of liquidation fillings the petitioner will have to pay the alimony and child support required from him before payment of any other non-secured debt according to section 212. Section 314 of the new act has also ruled that many unnecessary types of debts which fall under chapter 13 will no longer be applicable. The credit system was the center of the federal bankruptcy reform passed in 2005 and these
Thursday, August 22, 2019
My Friends Most Important Decision Essay Example for Free
My Friends Most Important Decision Essay Firstly, I would like to introduce my friend Jenny, who was born in China and now she is 25 years old. In 2011, she left her great job and came to the United States to pursue her master degree. Jenny decided to study in the United States and in particular at JWU because she wanted to study professional knowledge of management and have a master degree, she believe the U.S is the origin of the MBA program and JWU is famous for its hotel management program. First and foremost, after graduation, Jenny worked at the Beijing Branch of Education Service Center for about three years. She has great expectations for her career and she wants to get a high position but itââ¬â¢s difficult for her. She said, You can see my academic background, I never studied any business knowledge, if I want to get high promotion, to study professional knowledge of management and have a master degree is important for me. Thus, she wanted to get an MBA to get more knowledge of management and improve all kinds of abilities and help herself with her career objective. Another reason why she decided to study in the U.S. is because she believe that the United States is the origin of the MBA program. The United States MBA program pays more attention to practical skills and ability development, like communication, leadership, control, decision making, influence and entrepreneurship. She thinks studying in America can advance her career and make her more competitive in her field. She said to me, Americans Hospitality management program is very strong. Because in America , many universities are famous for this program, like: Cornell University, University of Houston, Pennsylvania State University, and the U.S. also has some famous hotel, like: Hilton Grand Vacations, New York Hotel and so on. Thus, she believes America is a good place for her to study this major. Most of all, Johnson Wales university is famous for its hotel management program. She has a friend who is currently studying hotel management at JWU, and her friend told her some advantages about this university, especially teaching resources on management is quite good. After that, she searched a lot of information on the internet, and found that JWU was suitable for her. She said, this university is career-oriented school, especially pay attention to students practical skill development, like communication, decision making, entrepreneurship and leadership ability. Many students who graduate from JWU can get into big companies like Hilton Hotel, so she believes studying at JWU can make her more competitive in the future. For these reasons and more, Jenny decided that in order to make herself more marketable that she needed to leave her job in China and move to the United States in order to learn professional knowledge and extend her education. Therefore, Jenny, my best friend, chose to study in the United States in an MBA program and in particular at JWU with a concentration in Hospitality.
Wednesday, August 21, 2019
Management of Security Essay Example for Free
Management of Security Essay Sever security is instrumental in enhancing authentication, authorization, and control of access to the network from a localized point. Therefore, implementation and management of security on windows server 2003 administration is important first because it enables easy and coherent configuring and maintenance of security setting and software installation on computer network systems. The quest for implementing security on windows server 2003 administration is failure by Microsoft to provide a single mechanism for security related settings configuration (Bragg, Hunt, 2005). The security components are attached to the server externally, a factor which makes remote monitoring and control of connections to the network by the server impossible without them. In addition, management of security in windows server 2003 is important in protecting the privacy and confidence of network users. Internet access has been on the rise in the community, an element that threatens confidentiality of computer information. Such are due to hacking and infecting of personal computers by malicious computer programs. On the other hand, security management in windows server 2003 administration serves the purpose of mitigating unauthorized access into the network. Moreover, this can also function to identify and prevent malicious computer programs from compromises services of the network users. Another important aspect of implementing and managing security in windows server 2003 is that it promotes monitoring and control of the network even when the server is offline. Employing security settings like Baseboard Management Controller hardware for example enables independent communication with remote computer. In return, this effectively enhances the process of remotely identifying errors and initiating response by the network administrator (McCann, Eckert, Schitka, 2005). Therefore, security implementation and management in windows server 2003 administration serves to reliability and efficiency service provision. References Bragg, R. , Hunt, C. (2005). Windows Server 2003 Network Administration. Sebastopol, CA: Oââ¬â¢Reilly. McCann, B. , Eckert, J. , Schitka, J. (2005). Managing a Microsoft Windows server 2003 Network, Enhanced. Mason, OH: Cengage Learning.
Tuesday, August 20, 2019
Isolation And Identification Of Enterococcus Faecium Biology Essay
Isolation And Identification Of Enterococcus Faecium Biology Essay Enterococci are widely distributed in the environment; within the human body, they are normal commensals of the oral cavity, gastrointestinal tract and vagina. Enterococcus faecium is a gram-positive bacterium group D, alpha hemolitic or nonhemolitic in the genus Enterococcus (Chingwaru W., 2003). It can be a commensal (non-harmful coexisting organism), in the human intestine, but it may also be a pathogen causing diseases like neonatal meningitis. Ordinary lactobacillus medium including: MRS medium, Luria-Bertani (LB) medium, high-sterilized stored at 4 à ¢Ã¢â¬Å¾Ãâ refrigerator spare. In the sterile console, the yogurt containing lactic acid bacteria was diluted with sterile saline to a serial dilution (10-3,10-4,10-5) of 50ÃŽà ¼l suspension and coated them on the plate containing MRS choice medium and marked. The plate was placed at 37à ¢Ã¢â¬Å¾Ãâ warm box without oxygen for 36 ~ 48 hours. Single colony was picked and repeatedly crossed to obtain the pure strains. Bacterial identification methods include the common (tradition) classified identification, numerical value identification and automation identificationà £Ã¢â ¬Ã¢â¬Å¡The common (tradition) classified identification needed to detect many items. It is so tedious. But numerical value identification is according to the identification target. It uses the test card. The result is expressed by the way of figure and compared with the data of database to get an identification result. Automation identification can reach whole procedure automation in the step of inoculation, cultivation, reading and report. It can supply a powerful instrument in rapid clinical microorganism diagnosis. No matter what kind of identification methods, it all needs to identify bacteria according to the morphology, physiological characteristics and biochemical characteristics. Enterococcus faecium is a kind of oval cell. Its diameter is 0.5 ~ 1.0 ÃŽà ¼m. It can show a short-chain arrangement frequently in pairs or in liquid medium. It has slight movement. In the blood plate it can form a milky white plate or white, marginal integrity, central protuberance, large and smooth colony. Its diameter is 1-2mm, and has rare colors, mostly around the colonies without hemolysis. After the Gram stain, bacteria shows purple. It is Gram-positive coccobacteria. The chemistry character of Enterococcus faecium is contact-negative, and it can grow in 6.5% broth, bile Esculin agar plate and 0.1à ¼Ã¢â¬ ¦methylene bue. It also can grow in 10à ¢Ã¢â¬Å¾Ãâ or 45à ¢Ã¢â¬Å¾Ãâ, pH 9.6 broth medium, and can tolerate 65à ¢Ã¢â¬Å¾Ãâ 30min condition. It can ferment lactose, sorbitol and mannitol and can use arginine, but cant use ferment arabinose. 2.3.2 Biochemical identification Identification by lactic acid bacteria and biochemical identification tests, respectively taking the exercise-induced, contiguity enzyme, anaerobic growth, l0à ¢Ã¢â¬Å¾Ãâ and 45à ¢Ã¢â¬Å¾Ãâ, 60à ¢Ã¢â¬Å¾Ãâ 30 min, 6.5à ¼Ã¢â¬ ¦NaCl salt-tolerant growth, pH 9.6 alkaline environment growth, methyl red, benzopyrrole, sugar alcohol acid fermentation (glucose, galactose, maltose, lactose, raffinose, manicol and so on). Comparing the experiment result with Bergers Manual of Determinative Bacteriology (the ninth edition) to determine comprehensively. 2.3.3 The growth curve of Enterococcus faecium The growth of bacteria includes increasing volume, quantity and the improvement of metabolic function. Different bacteria have their own different growth pattern. Under the unchanged culture conditions, calculate the number of bacteria oriented to time, time as abscissa, the number of bacteria as vertical axis we can get a curveà £Ã¢â ¬Ã¢â¬Å¡The growth curve includes the stagnation period, logarithmic phase, stationary phase and decline phase. The length of each period is different according to the medium composition and culture conditions due to bacterias own characteristics. In a comparative study of different bacteria, growth curve can help to choose bacterium with the same growth stat and this can make a reliable experiment result. Detect the bacteria-growth curve mainly use two methods, such as turbidity method and viable organism dilution count. Turbidity method is to place the different stage and different concentration bacterial culture to the spectrophotometer, and count the bacteria by turbidity method. We can use the turbidity to represent the yield of bacterium and measure total dacterial count (including the dead bacterium). It is simple, facility comparing with the turbidity method. But it only can indicate the bacterial relative growth information. Viable organism dilution method of counting is to dilute the bacterial liquid to different dilution of 10-1à £Ã¢â ¬Ã 10-2 and so on. Every dilution can be cultured in the plate and colony is counted with colony events-per-unit-time meter. The total quantity of viable organism by using this method can represent the true growth information of bacterium. 3 Application of Enterococcus faecium 3.1 Supplementation of dood with enterococcus faecium (SF68) stimulates immune functions The intestinal microflora play a crucial role in host defense as demonstrated by their ability to modulate both innate and acquired immunity at the local as well as systemic levels. Due to these immunological properties, specific strains of lactic acid bacteria (LAB),3 defined as probiotics, have raised considerable interest in recent years. When ingested as a feed supplement in sufficient numbers, probiotics are live microorganisms that beneficially affect the gastrointestinal balance, going far beyond the conventional nutritional effect. The mechanisms underlying the immune modulating properties of probiotics are not fully understood. However, they may be due indirectly to the ability of probiotics to balance the intestinal microflora and/or be a consequence of a direct adjuvant effect on the production of immune factors, such as cytokines. In fact, several strains of LAB were shown to enhance nonspecific immunity in vitro as well as in vivo, including the release of tumor necrosis factor-ÃŽà ± and interleukin 6 (4), increased phagocytosis in mice and humans (Perdigon, G. et al, 1988) (Schiffrin, E. J. et al, 1995) and stimulated natural killer cell activity (Matsuzaki, T., 1998, aller, D. et al, 2000). Their ability to specifically modulate the hosts immune responses to pathogens was also demonstrated (Meydani, S. N. Ha, W. K. , 2000). An increase in rotavirus-specific antibodies was detected in children with acute rotavirus diarrhea who received Lactobacillus rhamnosus (Kaila, M. et al, 1992). Moreover, it was shown that administration of L. johnsonii to human volunteers boosted the specific immunoglobulin IgA response to the Salmonella typhi vaccine Ty21a (Link-Amster, H. et al, 1994). 3.2 Application in treatment Enterococcus fececium can ferment a variety of sugar, and product acid. It has high chemical patience, and is widely distributed in nature, but also human and animal gut microbial. It has highly detected in animal feces (Archimbaud, C. et al., 2003). Ultilizing non-toxic, facultative anaerobic Enterococcus, in conjunction with other animal probiotics (Animal Microecologicai Agent, AMEA) can prevent and treat many digestive tract diseases of animals by replaceing antibiotics. Intestinal flora can be regarded as a normal human body organs, these normal floras directly involved in the activities of the host metabolism is normal physiological activities of the host indispensable component (Baldassarri, L. et al., 2001). Endogenous Enterococcus as one of the normal floras of the human body, mainly the Ministry of colonization in the ileum and colon, and some strains may be directly involved in the metabolism of the host material. Enterococcus lactic acid feces as intestinal flora, with a bio-barrier function, from healthy people or animals that have separate physiological functions of bacteria to re-giving taking it right people are harmless and safe, but such micro-organisms in the body and settled and reproduction Ecology is a very complex issue. Made viable by the agent is likely to play a biological activity within a certain range, or part of participation in host metabolic activity, resulting in a certain physiological role and therefore have the disease , adjusting the significance of the ecological balance (Chow, J. W. et al., 1993). Intestinal flora can be regarded as normal human body organs. These normal floras directly involved in the activities of the host metabolism, and are normal physiological activities of the host indispensable component. Endogenous Enterococcus as one of the normal floras in human body, mainly permanent plant in the ileum and colon, and some strains may be directly involved in the metabolism of the host material. Enterococcus faecium as intestinal flora, has a bio-barrier function. Enterococcus faecium separated from healthy people or animals also have physiological functions Re-giving to people is harmless and safe, but plant and reproduction in the body is a very complex ecology issue. Viable organism praeparatum is likely to play a biological activity within a certain range, or part of participation in host metabolic activity. It products a certain physiological role and therefore can be used in the disease provention, treatment and the ecological balance adjustment. Currently, the application of enterococci is mainly in Enterococcus faecium. The earliest example of the use of Enterococcus faecium is out of Japan. It was first developed for the treatment of various intestinal diseases. Yogurt products on the market are containing Enterococcus faecium in Japan or pharmaceutical drugs, such as Lascpan, Lacton, Ruosu, Lebenin, Biosmin. Mummy Love that product in South Korea contains 108 / g feces enterococci and it can treat gastro-intestinal diseases in infants probiotic preparations (Coque, T. M. et al., 1995). 3.3 Safety of Enterococcus faecium Endogenous intestinal bacteria, especially the colonization of lactic acid bacteria in the gut healthy people, the people are safe, because a large number of endogenous enterococci colonization in the human intestinal tract under the bit, which may affect the host intestinal digestion and absorption, and other function. It has been reported (Dicuonzo, G. et al., 2001) that yogurt containing Enterococcus faecium can prevent diarrhea. By double-blind test, the incidence of antibiotic group was 27.2%, while taking the probiotic group was only 3.7%. So it is not only proved to be effective, but did not find any side effects. In 1989 Food and Drug Administration (FDA) and the American Association of Feed Public (AAFCO) has also introduced the safety 42 probiotic bacteria, including Enterococcus faecium. 3.4 Oral application of Enterococcus faecium strain EE3 Probiotic administration is being used increasingly in human and veterinary medicine. A variety of microorganisms, especially lactic acid bacteria (LAB), such as lactobacilli, bifidobacteria, and enterococci nonpathogenic LAB are associated with a wide variety of sources, such as plant material and various foods. Based on the definition of probiotics, adequate numbers of viable organisms must reach the intestinal tract to have a beneficial effect. For this to happen, probiotic organisms must be able to survive transit through the acidic environment of the stomach and persist in the presence of bile. They have to multiply at the site of destination in the intestine. In addition, they must be able to produce the antagonistic metabolites against dominating saprophytic microflora resulting in competitive growth. Antimicrobial activity of LAB is due to the production of organic acids (lactic and acetic acids in particular), carbon dioxide, ethanol, hydrogen peroxide, biacetyl and bacterio cins. These abilities are ofen found among lactobacilli and enterococci, which are most frequently used as animal feed supplements or directly as probiotic preparations. Among enterococci, only the species of Enterococcus faecium of hunman origin was used as a commercial probiotic. E.faecium used as probiotics efficiently protect animals from diseases caused by E.coli, salmonellae or clostridia; it is also reported (Eaton, T. J. Gasson, M. J., 2001) that the best preventive effectivity of E.faecim from commercial probiotic preparation Vitacanis against Salmonella enterica serovar Typhimurium in the gastrointestinal tract of gnotobiotic mice. E.faecium EE3 train was able to survive transit through the canine intestinal tract, leading to enrichment of the colonic microflora and local and systematic effects. This strain also persisted in the digestive tract for almost 3 months after cessation of its administration. The new canine probiotic strain of Lactobacillus fermentum AD1 persisted in the feces of dogs even for 5 months after cessation, however, it reached a lower final concentration (103~105 CFU/g) than the EE3 strain (105~108 CFU/g). On the other hand, the well-known probiotic strain Lactobacillus fermentum GG survived in the healthy dogs only 8d after cessation of its administration. From the clinical point of view, persistence during administration should be less important than colonization. However, the potential probiotic microorganism should be able to colonize the digestive tract at least temporarily. Decrease of total enterococci can be explained probably by competitive interactions of the EE3 strain with othe r enterococci. Although enterococci normally producted lactic acid, its higher amounts (as the other enterococci) could be achieved by the concentration of inoculated EE3 strain; in addition, differences in lactic acid production were found among enterococci isolated from different sources. Local effects of the EE3 strain application included an increase of LAB and a significant decrease of Pseudominas-like bacteria and staphylococci with prolonged effect up to the end of the experiment It is reported that a significant increase in fecal LAB during administration of food supplemented with probiotic strain L.acidophilus DSM 13241. However, the action of the probiotic, in terms of its effect towards the number of lactobacilli, was lost after cessation of food supplemented with the same probiotic strain (L.acidophilus DSM 13241.). E.faecium EE3 strain survived the transit through the digestive tract of dogs. Our results suggested that bacteria and staphylococci. Moreover, the levels of total lipids, proteins and cholesterol in blood of healthy dogs were also influenced to reach physiological limits. 3.5 Application of Enterococcus faecium strain M-74 The value of managing atherosclerosis risk factors has been confirmed in the past few decades. Hypercholesterolemia, hypertension and smoking are still considered to be the classical risk factors. Intervention trials have generally shown that lowering risk factors reduces the subsequent rate of cornonary heart disease, stroke, and other cardiovascular diseases. The Framingham Study was the major study, which verified that cholesterol increases the risk of developing heart disease. Data output was clear: the risk of clinically apparent coronary heart disease is a continuous nonlinear function of blood cholesterol levels. Each increase in the serum cholesterol concentration by 1% results in 2~3% increase in the risk of CHD. The discovery that hypercholesterolemia plays a major role in the formation and development of atherosclerosis has led to a number of pharmacological and non-pharmacological (including dietary) approaches resulted in its elimination. Fact that the serum cholesterol concentration is influenced by food has been known for a long time ago. Later, the first evidence of affecting cholesterol level by influencing intestinal microflora was found. One way to do this is by using probiotics. Up to now, the question of supposed hypocholesterolemic effect of probiotics has not been definitely established. While some studies documented it well, others bring contradictary findings or even doubt it. Another unresolved issue is an existing previously mentioned effect from the long term point of view. In available sources, we have not found any report where probiotics were administrated for one year. Some experimental and clinical studies have documented the hypocholesterolemic effect of rpobiotic cultures. Not all of the probiotics seem to have the same properties and same effect on serum cholesterol levels. The aim of our study was to investigate the impact of long-term orally administered probiotic strain Enterococcus faecium M-74 enriched with selenium on l ipid profile (total cholesterol, LDH, HDL and triglycerides) in humans. Originally, the term probiotics was used for a phenomenon, when each of both together cultivated organisms had produced substances stimulating the growth of the another one. The meaning of the term probiotic has been evolving since. Many definitions have been suggested. The most commonly used, scientifically valid and therefore acceptable one is that postulated by Fuller. According to him, probiotics are living microorganisms that favourably influence the heath of the host by improving composition of its intestinal microflora. The FAO (Food and Agriculture Organisation for the United Nations) and WHO (World Health Organisation) refer to probiotics as living microorganisms which when ingested in sufficient amount, beneficially influence the health of the host. Before a certain bacterial strain can be classified probioticm it must meet some criteria. The most important one is its beneficial health effect. The knowledge of probiotic intervention in lipid metabolism is not new. In the 19 70s, researchers observed hypocholesterolemic effect of yoghurt eaten daily in large amount in humans. Similar observations have been seen in animal studies. Many trials aimed to proving the hypocholesterolemic effect of milk and fermented milk products come from early observation. It is found that a low incidence of clinical coronary heart disease in some African tribes with low cholesterol levels in spite of their diet rich in saturated fats, meat and cholesterol but abundant in milk and fermented milk products along. In some studies it is observed that a gradual decrease of serum cholesterol concentration in subjects receiving capsules with Enterococcus faecium M-74 from baseline up to week 23 when the decrease exceeded significant level (P
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